Nurses and midwives are on the frontlines of the health care workforce, so they should have evidence knowledge to deliver the care and information in a therapeutic, nonbiased manner to the aborted woman.

Aim: This study aims to evaluate the effectiveness of implementing evidence-based guidelines on nurses' knowledge regarding caring for aborted women.

Subjects and Methods: Quasi-experimental research design (one group pre-test, post-test) was utilized to fulfill the aim of this study.

Setting: This study was conducted in obstetrics, labor, and gynecological departments at Minia university hospital for maternity and child.

Sample: convenient sample included 55 nurses.

Tool: A self-administered questionnaire was used.

Results: The study's main findings revealed that nearly three-quarters of the studied nurses (72.7%) had a poor level of total knowledge regarding abortion before implementing evidence guidelines. However, 89.1% and 74.6% of them had good knowledge in immediate and Post three months after evidence guidelines, respectively, with statistically significant differences between pre and post-implementation of evidence-based guidelines in which p-value < 0.001. In addition, there was a statistically significant relation between pre-test knowledge of nurses with their age and year of experience in which P-value ≤ 0.0009 & 0.0003 respectively.

Conclusion: Implementing evidence-based guidelines effectively significantly improved nurses' knowledge of caring for aborted women.

Recommendation: The nursing curriculum should include updated evidence-based knowledge in abortion care and the distribution of brochures and pamphlets for nurses as guidance concerning abortion.