Background: Polycystic ovarian disease is a heterogeneous, multisystem endocrinopathy in women of reproductive age with the ovarian expression of various metabolic disturbances and a wide spectrum of clinical features such as obesity, menstrual abnormalities and hyperandrogenism.

Methodology: A quantitative approach with pre-experimental one group pretest post-test design was adopted for the study. The samples from the selected PUC and degree colleges from Kalaburgi were selected using convenient sampling technique. The sample consisted of 50 adolescent girls. The tools used for data collection was structured knowledge questionnaire.

Results: The study result reveal that, Pretest knowledge scores ranged from 6-20 as against possible range of 0- 30. The mean pretest knowledge score is 12.04 with standard deviation ±3.29 and the median score is 12. The posttest knowledge scores ranged from 16-30 as against possible range of 0- 30. The mean of posttest knowledge scores is 23.52 with standard deviation ±3.64 and median of 24 in group. The mean difference between the pretest and posttest knowledge mean scores is 11.48. This indicates an increase in knowledge scores after undergoing self-learning material. To find significance of the gain in knowledge paired ‘t’ test value was computed and the obtained value of‘ t’ (49) = 27.12 is found to be significant at 0.05 level of significance.

Conclusion: Health care professionals should give importance of health education on various reproductive health problems in school health programme and take interest to promotion of health among adolescent population. This study gave the evidence that, through self-learning material, knowledge of adolescent girls regarding health-related behaviour can be improved.