Introduction: Evidence-based recommendations for hysterectomy patients are regarded as an approach for enhancing their wellness and health.

The Aim: Evaluate the effect of implementing evidence-based practices guidelines on women's knowledge regarding self-care after hysterectomy.

Subjects and Methods: (one group pre & post-test) a quasi-experimental design was used. A purposive sample of sixty women was documented in this study that was performed at gynaecological departments of Minia university hospital, Egypt. Also utilized three tools in this study.

(I): Structured interview questionnaire.

(II): Structured questionnaire on women's knowledge.

(III): Follow up questionnaire to assess health problems experienced 6 weeks after hysterectomy and developed supportive material (Arabic booklet).

Results: About (88.30%) of women had inadequate knowledge regarding self-care after hysterectomy in the pre-test. While, following the implementation of the recommendations for evidence-based practices, it was found that women's overall knowledge had improved in a highly statistically significant way (p≤ 0.001). The most usual health problem women experienced 6 weeks after hysterectomy was night sweats & hot flashes (86.6%).

Conclusion: Implementing evidence-based practices guidelines was significantly improved women’s knowledge regarding self-care after hysterectomy.

Recommendations: Updated discharge plan involving evidence-based practices guidelines in relation to self-care after hysterectomy should be included in habitually care for women undergoing hysterectomy.