Objectives: To assess the prevalence of postnatal depression among mothers of infants admitted in NICU.

Method: A cross-sectional survey carried out on 120 mother’s Non-probability convenient sampling was adopted. Mothers were interviewed according to the, Edinburg Postnatal Depression Scale (EPDS) on day 6 to day 8 of admission of the newborn to assess the prevalence of postnatal depression among Mothers of preterm babies who were admitted in the NICU

Results: Sixty-two mother’s demonstrated depressive symptoms with score more than 13 on the EPDS Scale which accounts for the prevalence of 51.66% of possible postnatal depression while fifty-eight (48.33%) mothers had no postnatal depression.

Conclusion: The experience of mothers with infants at the NICU is a complex event. Every woman has different resilience parameters women suffering from depression should seek medical attention.